SPATIAL DISTRIBUTION AND PREDICTIVE SIGNIFICANCE OF DENDRITIC CELLS AND MACROPHAGES IN ESOPHAGEAL CANCER TREATED WITH COMBINED CHEMORADIOTHERAPY AND PD-1 BLOCKADE

BackgroundThe first clinical study (NCT03671265) of first-line chemoradiotherapy combined with PD-1 blockade showed promising treatment outcomes in locally advanced esophageal squamous cell carcinoma (ESCC).However, partial patients did not respond to the combination treatment.The roles of dendritic cells (DCs) and macrophages in this combination t

Not all accidental releases of flammable gases and vapours create explosions; most releases do not find an ignition source and of those that do ignite, most of them generate low or moderate overpressure only (deflagrative combustion).However, when certain conditions are satisfied, deflagration to detonation transition (DDT) can occur followed by st

The genetic, structural, and functional characteristics of the human body are of particular importance for the manifestation of motor abilities.The aim of the survey was to reveal the character and the degree of the relationship between the basic anthropometric para meters Pump Inlet Casing and the main motor abilities in preschoolers.208 boys and

Tuna is one of the most widely consumed fish on the European market, being available in various consumable options.Among them, Thunnus albacares, also called yellowfin tuna, is a delicacy and is consumed by millions of people around the world.Due to its comparatively high cost and demand, it is more vulnerable to fraud, where low-cost tuna or other